Daytime sleepiness and polysomnography in obstructive sleep apnea patients

• DOI: 10.1016/j.sleep.2008.02.006
• Publication Date: 2008-05-16T13:19:12Z
• Authors: Nuria Roure; Silvia Gomez; Olga Mediano; Joaquin Duran; Monica de la Peña; Francisco Capote; Joaquin Teran; Juan Fernando Masa; Maria Luz Alonso; Jaime Corral; Angeles Sánchez-A...; Cristina Martinez; Antonia Barceló; David Gozal; Jose Maria Marín; Ferran Barbé
• Keywords: Adult; Male; Sleep Apnea, Obstructive; Polysomnography; Age Factors; Disorders of Excessive Somnolence; Middle Aged; Circadian Rhythm; Cohort Studies; Oxygen; Sleep Apnea Syndromes; Risk Factors; Humans; Female; Sleep Stages; Arousal; Aged

Excessive daytime sleepiness (EDS) is the major complaint in subjects with obstructive sleep apnea syndrome (OSAS). However, EDS is not universally present in all patients with OSAS. The mechanisms explaining why some patients with OSAS complain of EDS whereas others do not are unknown.To investigate polysomnographic determinants of excessive daytime sleepiness (EDS) in a large multicenter cohort of patients with obstructive sleep apnea (OSAS).All consecutive patients with an apnea-hypopnea index greater than 5h(-1) who were evaluated between 2003 and 2005. EDS was assessed using the Epworth Sleepiness Scale (ESS), and patients were considered to have EDS if the ESS was >10.A total of 1649 patients with EDS ((mean [+/-SD] Epworth 15+/-3) and 1233 without EDS (Epworth 7+/-3) were studied. Patients with EDS were slightly younger than patients without EDS (51+/-12 vs 54+/-13 years, p<0.0001), had longer total sleep time (p<0.007), shorter sleep latency (p<0001), greater sleep efficiency (p<0.0001) and less NREM sleep in stages 1 and 2 (p<0.007) than those without EDS. Furthermore, patients with EDS had slightly higher AHI (p<0.005) and arousal index (p<0.001) and lower nadir oxygen saturation (p<0.01).Patients with OSAS and EDS are characterized by longer sleep duration and increased slow wave sleep compared to those without EDS. Although patients with EDS showed a mild worsening of respiratory disturbance and sleep fragmentation, these results suggest that sleep apnea and sleep disruption are not the primary determinants of EDS in all of these patients.