Bariatric surgery decreased the serum level of an endotoxin-associated marker: lipopolysaccharide-binding protein

• DOI: 10.1016/j.soard.2014.02.022
• Publication Date: 2014-02-27T15:02:08Z
• Authors: Po-Jen Yang; Wei-Jei Lee; Ping-Huei Tseng; Po-Huang Lee; Ming-Tsan Lin; Wei-Shiung Yang
• Keywords: Adult; Male; Gastroplasty; Gastric Bypass; Bariatric Surgery; Body Mass Index; Cohort Studies; 03 medical and health sciences; Gastrectomy; Humans; 2. Zero hunger; 0303 health sciences; Membrane Glycoproteins; Middle Aged; 16. Peace & justice; Obesity, Morbid; 3. Good health; C-Reactive Protein; Multivariate Analysis; Linear Models; Female; Carrier Proteins; Biomarkers; Acute-Phase Proteins; Follow-Up Studies

Recent studies have shown serum lipopolysaccharide binding protein (LBP) is associated with obesity and related metabolic disorder. Bariatric surgery can significantly reduce weight, but reports about the change of LBP after bariatric surgery are limited. We investigated LBP concentration and its associations with clinical variables.We enrolled 178 obese patients receiving different bariatric surgeries and 38 normal weight individuals. Fasting blood samples were collected at baseline in all and 1 year after surgery in obese individuals. The serum LBP concentration was measured.The percentage of excess weight loss of mini-gastric bypass, Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric band were 72.0±20.0%, 65.5±23.0%, 67.2±18.4%, and 16.1±14.3%, respectively. Serum LBP levels were higher in the obese participants than in the normal weight participants (49.9±15.7 versus 25.2±7.5 μg/mL; P<.001) at baseline and significantly decreased to 35.1±22.6 μg/mL after bariatric surgery (P<.001) in the obese group. In the bariatric participants, after multivariate analyses, preoperative LBP and the change of LBP with surgery were independently associated only with high sensitive C-reactive protein (hs-CRP) (P<.001) and the change of hs-CRP (P = .012), respectively, while none of the postoperative variables was independently associated with LBP.LBP is associated with body mass index and hs-CRP. Bariatric surgery significantly decreased the serum level of LBP. The relationship between LBP and hs-CRP disappeared after bariatric surgery.