COVID-19 patients with obesity at risk for worse outcomes despite younger age and fewer inflammatory derangements

• DOI: 10.1016/j.soard.2021.06.006
• Publication Date: 2021-06-24T13:35:29Z
• Authors: Claire L. Le Guen; Neil A. King; Huaqing Zhao; Elizabeth P. Renz...; Glenn S. Gerhard; Rohit S. Soans
• Keywords: 2. Zero hunger; Intensive Care Units; SARS-CoV-2; COVID-19; Humans; Original Article; Obesity; Child; Retrospective Studies; 3. Good health

BackgroundCoronavirus disease 2019 (COVID-19) is a viral pulmonary infection that can progress to cytokine storm syndrome because of widespread dysregulated inflammatory response. Many patients at risk for severe COVID-19 manifestation have been identified as those with preexisting conditions origin, well impair appropriate immune response, such obesity.ObjectivesThe aim this study describe the manifestation, clinical course, and biomarker milieu in obesity.SettingUniversity Hospital Philadelphia, Pennsylvania.MethodsIn retrospective cohort study, 600 who were positive stratified by World Health Organization (WHO) obesity class their presenting symptoms, biomarkers, demographics, outcomes (intubation rate, intensive care unit [ICU] admission, length stay [LOS], mortality) investigated.ResultsAge was inversely related class; III presented 12.9 years younger than normal weight (P < .0001). Initial ferritin lab values negatively correlated increasing = .0192). Normal or near-normal lymphocyte profile noted compared without .0017). Patients had an increased rate ICU admission .0215) .0004), but no differences intubation .3705) mortality .2486).ConclusionPatients more likely present hospital age, reduced levels disturbances, LOS rates, although not mortality.