Intraperitoneal oxygen microbubble therapy: A novel approach to enhance systemic oxygenation in a smoke inhalation model of acute hypoxic respiratory failure

• DOI: 10.1016/j.sopen.2023.09.020
• Publication Date: 2023-10-11T23:25:54Z
• Authors: Premila D. Leiphr...; Hannah R. Weber; Kirk W. Foster; Keely L. Buesing
• Keywords: Bolus (digestion)

Patients suffering from severe acute respiratory distress syndrome (ARDS) face limited therapeutic options and alarmingly high mortality rates. Refractory hypoxemia, a hallmark of ARDS, often necessitates invasive high-risk treatments. Oxygen microbubbles (OMB) present promising approach for extrapulmonary oxygenation, potentially augmenting systemic oxygen levels without exposing patients to significant risks.Rats with severe, hypoxemia secondary wood smoke inhalation (SI) received intraperitoneal (IP) bolus injections escalating weight-by-volume (BW/V) OMB doses or normal saline determine optimal dosage treatment efficacy. Subsequently, 10 % BW/V was administered group SI rats control healthy (SHAM). Imaging, vital signs, laboratory studies were compared at baseline, post-smoke inhalation, post-treatment. Histological examination lung tissue wet/dry weight ratios assessed study conclusion.Treatment various in SI-induced revealed that dose significantly augmented while minimizing volume. The second set demonstrated increase partial pressure arterial (PaO2) normalization heart rate the treatment.This highlights successful augmentation oxygenation following small animal model hypoxemia. therapy emerges as novel modality immense translational potential support care settings.