A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

• DOI: 10.1016/j.stemcr.2019.09.006
• Publication Date: 2019-10-17T14:42:33Z
• Authors: Celeste M. Karch; Aimee W. Kao; Anna Karydas; Khadijah Onanuga; Rita Martinez; Andrea Argouarch; Chao Wang; Cindy Huang; Peter Dongmin Sohn; Kathryn R. Bowles; Salvatore Spina; M. Catarina Silva; Jacob A. Marsh; Simon Hsu; Derian A. Pugh; Nupur Ghoshal; Joanne Norton; Yadong Huang; Suzee E. Lee; William W. Seeley; Panagiotis Theofilas; Lea T. Grinberg; Fermin Moreno; Kathryn McIlroy; Bradley F. Boeve; Nigel J. Cairns; John F. Crary; Stephen J. Haggarty; Justin K. Ichida; Kenneth S. Kosik; Bruce L. Miller; Li Gan; Alison M. Goate; Sally Temple; Carolina Alquezar; Kathryn Bowles; David Butler; John F. Crary; Li Gan; Alison M. Goate; Stephen J. Haggarty; Israel Hernandez; Valerie Hennes; Cindy Huang; Justin K. Ichida; Martin Kampmann; Aimee W. Kao; Celeste M. Karch; Anna Karydas; Kenneth S. Kosik; Rita Martinez; Khadijah Onanuga; M. Catarina Silva; Sally Temple; Chao Wang
• Keywords: Primary (astronomy)

Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically diverse neuropsychiatric, cognitive, motor impairments. Autosomal dominant mutations in MAPT gene cause heterogeneous frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common rare variants increase risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) corticobasal (CBD). We generated a collection fibroblasts from 140 mutation/risk variant carriers, PSP, CBD, cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines mutation non-carrier family members, autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; forebrain neural progenitor cells (NPCs). Here, we present resource fibroblasts, iPSCs, NPCs comprehensive clinical histories can be accessed scientific community disease modeling development novel therapeutics tauopathies.