Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

• DOI: 10.1016/j.stemcr.2019.12.008
• Publication Date: 2020-01-16T15:33:14Z
• Authors: Insoo Hyun; Megan Munsie; Martin F. Pera; Nicolas C. Rivron; Janet Rossant
• Keywords: 570; Medicine (General); 0303 health sciences; Internationality; QH301-705.5; Forum; Stem Cells; Life Sciences; 610; Guidelines as Topic; Embryo, Mammalian; Models, Biological; Embryo Research; 03 medical and health sciences; R5-920; Medicine and Health Sciences; Humans; Biology (General); JMG

Over the past few years, a number of research groups have reported striking progress on generation in vitro models from mouse and human stem cells that replicate aspects early embryonic development. Not only do these reproduce some key cell fate decisions but, especially system, they also mimic spatiotemporal arrangements extraembryonic tissues are required for developmental patterning implantation uterus. If such could be developed embryo, would great potential benefits understanding development, biomedical science, reducing use animals embryos research. However, guidelines ethical conduct this line work at present not well defined. In Forum article, we discuss emerging area provide recommendations its oversight.