Development of PLA suture materials by extrusion, electrospinning and supercritical CO2 impregnation of ibuprofen and naproxen

• DOI: 10.1016/j.supflu.2023.105854
• Publication Date: 2023-01-20T07:32:59Z
• Authors: Patricia Rivera; Carolina Villegas; Rene Cabezas; Barbara Pérez; Alejandra Torres; Carol López de Di...; Luan Garrido; Paula Galvez; Claudio Araya; Julio Romero
• Keywords: Supercritical carbon dioxide; Electrospinning; Extrusion; Impregnation; Suture materials; 01 natural sciences; Drug delivery systems; 0104 chemical sciences

Peer reviewed<br/>The authors are grateful for the financial support to the Project Fondecyt 1190302 (ANID-Chile) and the Basal Financing Program for Scientific and Technological Centers of Excellence CEDENNA (Grant no. AFB180001). R. Cabezas is also gratefully acknowledged to the Project POSTDOC DICYT 0218111RF University of Santiago de Chile. C. López de Dicastillo is also gratefully acknowledged to the "Ramón Cajal" Fellowship RYC2020-029874 financed the Spanish Ministry of Science and Innovation. C. Villegas is also gratefully acknowledged to the ANID Fondecyt Postdoctoral Project 3210434 and USA1799 Vridei081971AG_GO University of Santiago de Chile. P. Rivera is grateful to The Agencia Nacional de Investigación y Desarrollo (ANID-Chile) through Ph.D. scholarship [Doctorado Nacional/2022-21221075].<br/>Suture materials based on poly (lactic acid) (PLA) were developed by means of two different methods: extrusion and electrospinning, which were followed by a supercritical CO2 impregnation treatment. Both suture materials obtained by these techniques were impregnated with naproxen and ibuprofen using supercritical CO2 as impregnation medium. The impregnation assays were carried out at two different pressures (12 and 15 MPa), a temperature of 40 °C and, a depressurization rate of 1 MPa/min. Depending on the drugs incorporated into the suture materials, the concentrations varied from 5.60 to 26.73 wt%. The addition of both drugs and, the preparation process itself caused different changes in the structural and thermal properties of the final suture materials. Finally, tests to quantify the kinetic release of both drugs were carried out in vitro by using a Franz diffusion cell, obtaining the concentration profiles of delivered compounds as a function of the time.<br/>