The uncharted territory of NAD+-capped RNA

• DOI: 10.1016/j.tcb.2023.12.005
• Publication Date: 2024-01-21T06:57:41Z
• Authors: Quan Ma; Jianzhao Liu; Hao Hu; Zisheng Luo

The critical redox cofactor NAD+ was recently reported to serve as an RNA cap in both eukaryotes and prokaryotes. However, its reversible regulation and biological functions remain unclear. Here, we provide insights into its discovery, capping and decapping mechanisms, for further discovery of their potential functional implications.