Reductive lithiation of alkoxy-substituted benzyl methyl ethers and connection with cross-coupling reactions

• DOI: 10.1016/j.tet.2003.11.085
• Publication Date: 2004-01-13T06:34:45Z
• Authors: Ugo Azzena; Giovanna Dettori; Roberta Pireddu; Luisa Pisano
• Keywords: Reduction; Lithiation; Cross-coupling.; 01 natural sciences; 0104 chemical sciences

Abstract 2-and 4-Ethoxymethoxybenzyl methyl ethers were employied as useful starting materials for the synthesis of 1,2- or 1,4-dicarbo-substituted benzenes. The proposed reaction sequence involves connection between the reductive lithiation of benzyl alkyl ethers and the metal-catalyzed cross-coupling reaction of aromatic triflates.