Rh-catalyzed novel α-fluoroalkylation of α,β-unsaturated ketones and its mechanism

• DOI: 10.1016/j.tet.2007.09.081
• Publication Date: 2007-10-03T11:12:27Z
• Authors: Kazuyuki Sato; Yoshitaka Ishida; Eriko Murata; Yumiko Oida; Yasumitsu Mori; Miho Okawa; Kayoko Iwase; Atsushi Tarui; Masaaki Omote; Itsumaro Kumadaki; Akira Ando
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Treatment of α,β-unsaturated ketones and fluoroalkyl halides with Et 2 Zn in the presence of RhCl(PPh 3 ) 3 gave novel reductive fluoroalkylation products at the α-position of α,β-unsaturated ketones in moderate to good yields. The rhodium hydride complex derived from Et 2 Zn and Rh catalyst seems to have played an important role in this reaction.