p-TsOH promoted Fischer indole synthesis of multi-substituted 2-trifluoromethyl indole derivatives

• DOI: 10.1016/j.tet.2010.01.080
• Publication Date: 2010-02-11T06:44:53Z
• Authors: Haizhen Jiang; Yangli Wang; Wen Wan; Jian Hao
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract A p-TsOH promoted one-pot synthesis of multi-substituted 2-trifluoromethyl indole derivatives, for instance, 2-trifluoromethyl-3-phenylindoles, 2-trifluoromethyl-indole-3-propanoates, and 2-trifluoromethyl-indole-3-butanoates from reactions of 1,1,1-trifluoro-3-phenylacetone and simply prepared ω-trifluoromethyl substituted δ and ɛ-ketoesters with arylhydrazines via Fischer indole synthesis has been developed.