Synthesis of 1,2,5- and 1,2,3,5-substituted pyrroles from substituted aziridines via Ag(I)-catalyzed intramolecular cyclization

• DOI: 10.1016/j.tet.2011.02.072
• Publication Date: 2011-03-07T19:21:55Z
• Authors: Jun Hee Kim; Sang Bin Lee; Won Koo Lee; Doo-Ha Yoon; Hyun-Joon Ha
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractSequential ring opening of propargylic aziridines (I) and (IV) with acetic acid and Ag(I)‐catalyzed nucleophilic recyclization provides a novel access towards hydroxymethylpyrrole derivatives (II) and (V), resp., in moderate to good yields.