Kadpolysperins A–N, lanostane triterpene acids possessing rich structure types from Kadsura polysperma

• DOI: 10.1016/j.tet.2012.03.116
• Publication Date: 2012-04-21T03:46:32Z
• Authors: Ke Dong; Jian-Xin Pu; Xue Du; Jia Su; Xiao-Nian Li; Jian-Hong Yang; Wei Zhao; Yan Li; Han-Dong Sun
• Keywords: Lanostane; Terpene

Fourteen new lanostane triterpene acids (1-14), and five known analogues (15-19) were isolated from the stems of Kadsura polysperma. Compound 1, with a rearranged tetracyclic skeleton, is an important biogenic precursor of longipedlactone skeleton. Compounds 2-6 are members of 18(13 -> 12)-abeo-lanostane triterpene acids. The structures of new compounds were elucidated by spectroscopic evidence. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. (C) 2012 Elsevier Ltd. All rights reserved.