Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea

• DOI: 10.1016/j.tet.2012.10.102
• Publication Date: 2012-11-15T11:03:15Z
• Authors: Jian-Fan Sun; Zhuang Han; Xue-Feng Zhou; Bin Yang; Xiuping Lin; Juan Liu; Yan Peng; Xian-Wen Yang; Yonghong Liu
• Keywords: Dichotella gemmacea; Natural products; Structure elucidation; 14. Life underwater; Antifouling agents; Diterpenoids; 01 natural sciences; Nontoxic; 0104 chemical sciences

Our continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 mu g/mL, respectively. (c) 2012 Elsevier Ltd. All rights reserved.