Highly enantioselective hydrogenation of N-unprotected indoles using (S)-C10–BridgePHOS as the chiral ligand

• DOI: 10.1016/j.tet.2013.06.016
• Publication Date: 2013-06-11T18:32:34Z
• Authors: Chao Li; Jianzhong Chen; Guanghong Fu; Delong Liu; Yangang Liu; Wanbin Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractIt appears that substituents at the 2‐position play a significant role in the Pd‐catalyzed asymmetric hydrogenation of indoles in the presence of a macrocyclic PHOS‐type ligand.