A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles

• DOI: 10.1016/j.tet.2014.03.106
• Publication Date: 2014-04-04T20:18:16Z
• Authors: Cevher Altuğ; Muhammet Büyükbayram; Özge Kavas; Muhsine Zeynep Yavuz
• Keywords: Cancer cell lines

Abstract The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using α-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a , 3c , 3e and 3h showed noticeable cytotoxic property against four cancer cell lines.