Synthetic trehalose di- and mono-esters of α-, methoxy- and keto-mycolic acids

• DOI: 10.1016/j.tet.2014.10.072
• Publication Date: 2014-11-01T12:32:49Z
• Authors: Juma'a R. Al Dula...; Mark S. Baird; Maximiliano Maza-...; Rwoa'a T. Hameed; Klarah S. Baols; Majed Muzael; Ahmed D. Saleh
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Synthetic mycolic acids matching the overall structure of the major mycolic acids of Mycobacterium tuberculosis are coupled to trehalose to generate the corresponding synthetic trehalose monomycolate (TMM) and trehalose dimycolate (TDM; cord factor), either with two identical or two different mycolic acids.