β-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp. PSU-ES123

• DOI: 10.1016/j.tet.2016.08.048
• Publication Date: 2016-08-22T23:09:33Z
• Authors: Praphatsorn Saetang; Vatcharin Rukacha...; Souwalak Phongpai...; Jariya Sakayaroj; Xiaofan Shi; Jing Chen; Xu Shen
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Five new metabolites including four β -resorcylic macrolides 1 – 4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound 1 displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 μg/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS-1 832/13 pancreatic β -cells by an EC 50 value of 6.09 μM and was noncytotoxic to Vero cells.