Synthesis and anti-bacterial activity of a library of 1,2-benzisothiazol-3(2H)-one (BIT) derivatives amenable of crosslinking to polysaccharides
BIT derivatives
Galactomannans
biocides; biostability <abstractend>; BIT derivatives; chemical coupling; galactomannans; biochemistry; drug discovery; pharmaceutical science; organic chemistry
Biostability<abstractend>
Biostability
Biocides
Chemical coupling
01 natural sciences
0104 chemical sciences
DOI:
10.1016/j.tet.2017.02.025
Publication Date:
2017-02-15T11:01:28Z
AUTHORS (7)
ABSTRACT
1,2-Benzisothiazol-3(2H)-one (BIT) is one of the most common chemical biocides in industrial products, with a heterocyclic structure and a wide range of antimicrobial activity. A library of BIT derivatives was synthesized and characterized, from which 18 compounds were selected, tested for anti-bacterial activity relative to the parent molecule and amenable of coupling to plant polysaccharides in general and to galactomannans (GM) in particular, widely used as rheology modifiers, but with limited "biostability". Four sites on the BIT core were targeted: the nitrogen and the oxygen atoms on the heterocyclic ring, the C5 and the C6 positions on the aromatic ring, where functional groups were introduced. The ultimate aim of this work is to establish whether by covalently linking a biocide to GM polymers, their "biostability" can be improved.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (128)
CITATIONS (18)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....