Straightforward convergent access to 2-arylated polysubstituted benzothiazoles

• DOI: 10.1016/j.tet.2020.130982
• Publication Date: 2020-01-30T16:49:10Z
• Authors: Omar Sadek; David M. Perrin; Emmanuel Gras
• Keywords: [CHIM.COOR]Chemical Sciences/Coordination chemistry; 01 natural sciences; 0104 chemical sciences

A modular access to 2,4 disubstituted benzothiazoles has been achieved though the intermediacy of 4-bromo-2-iodobenzothiazole. The difference in reactivity of both halogens was advantageously exploited to achieve sequential Suzuki-Miyaura cross-coupling giving access to a range of polyaromatic derivatives featuring a central benzothiazole core.