Regioselective oxidation of N -alkylpyrrolidines to pyrrolidin-5-ones by RuCl 3 /NaIO 4

• DOI: 10.1016/j.tetlet.2003.12.072
• Publication Date: 2004-01-16T10:15:44Z
• Authors: Nagendra K. Sharma; Krishna N. Ganesh
• Keywords: Methylene; Heteroatom; Pyrrolidine

RuCl3/NaIO4 under EtOAc/H2O biphasic conditions, selectively oxidizes the Nα-endo-methylene group of pyrrolidine derivatives, without affecting the exo-methylene group adjacent to the N-heteroatom. RuCl3/NaIO4 under EtOAc/H2O biphasic conditions, selectively oxidizes the Nα-endo-methylene group of pyrrolidine derivatives, without affecting the exo-methylene group adjacent to the N-heteroatom.