Indium(III) bromide catalyzed one-pot synthesis of trichloromethylated tetrahydropyrimidinones

• DOI: 10.1016/j.tetlet.2004.10.048
• Publication Date: 2004-11-06T13:03:10Z
• Authors: Marcos A.P. Martins; Marcos V.M. Teixeira; Wilson Cunico; Elisandra Scapin; Rodrigo Mayer; Claudio M.P. Pereira; Nilo Zanatta; Helio G. Bonacorso; Clóvis Peppe; Yao-Feng Yuan
• Keywords: One-pot synthesis

Abstract One-pot condensation of ethyl trichloroacetoacetate 1 with p -substituted aromatic aldehydes (Ph, 4-Me–C 6 H 4 , 4-Cl–C 6 H 4 , 4-MeO–C 6 H 4 ) or furfural, and urea or thiourea catalyzed by indium(III) bromide affords eight trichloromethylated tetrahydropyrimidinones, in high yields.