Synthesis of tunable phosphinite–pyridine ligands and their applications in asymmetric hydrogenation

• DOI: 10.1016/j.tetlet.2006.04.111
• Publication Date: 2006-05-25T20:15:23Z
• Authors: Qi-Bin Liu; Chang-Bin Yu; Yong-Gui Zhou
• Keywords: 01 natural sciences; 0104 chemical sciences

A new class of modular conformationally rigid N,P ligands is conveniently synthesized from readily available starting material. Iridium complexes with these ligands have demonstrated excellent enantioselectivity (up to 99% ee) in the asymmetric hydrogenation of aryl alkenes.