Synthesis of phosphorylcholine–oligoethylene glycol–alkane thiols and their suppressive effect on non-specific adsorption of proteins

• DOI: 10.1016/j.tetlet.2009.04.091
• Publication Date: 2009-05-05T08:42:20Z
• Authors: Mutsuo Tanaka; Takahiro Sawaguchi; Yukari Sato; Kyoko Yoshioka; Osamu Niwa
• Keywords: Phosphorylcholine; Alkane; Thiol

Abstract A series of phosphorylcholine–oligoethylene glycol–alkane thiols were synthesized, and their suppressive effect on the non-specific adsorption of proteins was evaluated by comparison with corresponding oligoethylene glycol–alkane thiols. It was found that phosphorylcholine–oligoethylene glycol–alkane thiols had a greater suppressive effect on the non-specific adsorption of proteins.