Enantioselective synthesis of decarestrictine J

• DOI: 10.1016/j.tetlet.2009.10.035
• Publication Date: 2009-10-14T18:47:29Z
• Authors: Partha Sarathi Ch...; Priti Gupta; Pradeep Kumar
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient total synthesis of decarestrictine J has been achieved using ring-closing metathesis and Yamaguchi esterification as key steps. The stereogenic centres were generated by means of iterative hydrolytic kinetic resolution (HKR) of racemic epoxides.