Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source

• DOI: 10.1016/j.tetlet.2014.04.082
• Publication Date: 2014-05-01T21:31:33Z
• Authors: A. Sivalingam Suresh; Poongavanam Babur...; Mansur Ahmed
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO)8 as carbonyl source making it readily accessible in small-scale laboratory applications.