Asymmetric synthesis of structural analogues of (+)-clusianone via enantioselective ACC alkylation

• DOI: 10.1016/j.tetlet.2015.01.012
• Publication Date: 2015-01-08T16:22:00Z
• Authors: Michelle R. Garnsey; Maulen M. Uteuliyev; Don M. Coltart
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The asymmetric total synthesis of four structural analogues of (+)-clusianone from a common advanced intermediate is described. Asymmetric induction is achieved through the use of enantioselective ACC alkylation, providing the common advanced intermediate with an er of 99:1.