A convenient and efficient approach to synthesize negletein from baicalin

• DOI: 10.1016/j.tetlet.2016.03.085
• Publication Date: 2016-03-30T00:28:33Z
• Authors: Guihua He; Yu Gao; Cailong Li; Guolin Wu; Yazhen Li; Longrong Dong; Changcang Huang; Haijun Chen
• Keywords: 0301 basic medicine; 03 medical and health sciences

Abstract A simple two-step/one-pot and highly efficient strategy for the synthesis of negletein from naturally abundant and inexpensive baicalin has been developed. In this one-pot sequence, esterification of baicalin catalyzed by concentrated H2SO4 in methanol followed by the treatment with excess NaBH4 afforded negletein in moderate yield. This method provides an additional approach for the synthesis of negletein.