Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

• DOI: 10.1016/j.tetlet.2016.10.097
• Publication Date: 2016-10-27T08:15:40Z
• Authors: Xuyun Chen; Yang Yu; Ziyang Liao; Hao Li; Wei Wang
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.