One-pot synthesis of tricyclo-1,4-benzoxazines via visible-light photoredox catalysis in continuous flow

• DOI: 10.1016/j.tetlet.2017.02.068
• Publication Date: 2017-02-22T21:31:42Z
• Authors: Guolin Wu; Tingting Lv; Wenhui Mo; Xiping Yang; Yu Gao; Haijun Chen
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract A facile one-pot synthesis of tricyclo-1,4-benzoxazines has been developed via metal-free intramolecular cyclization of indole derivates. These reactions were efficiently achieved at ambient temperature by using visible-light photoredox catalysis in continuous flow. This directed intramolecular cyclization could be easily handled and scaled up in an open flask, enabling construction of a focused compound library for further pharmacological evaluation.