Ligand-free copper-catalyzed direct amidation of diaryliodonium salts using nitriles as amidation reagents

• DOI: 10.1016/j.tetlet.2021.153048
• Publication Date: 2021-03-31T14:14:10Z
• Authors: Hui-cheng Cheng; Lichao Zhou; Xuming Zhou; Jiao-li Ma; Penghu Guo; Yang Zhang; Hong-bing Ji
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract An efficient and practical methodology for the synthesis of N-arylamides has been developed via copper-catalyzed amidation of diaryliodonium salts with nitriles. Various substituted aryl nitriles and aliphatic nitriles could be applied in the reaction, providing a series of N-arylated amides in moderate to good yields. This procedure provides an alternative route for the synthesis of various N-arylamides. A proposed mechanism based on control experiments is also presented.