Resuscitation-promoting factors possess a lysozyme-like domain

• DOI: 10.1016/j.tibs.2003.10.009
• Publication Date: 2003-11-20T08:04:02Z
• Authors: M Cohen-Gonsaud
• Keywords: Models, Molecular; 0301 basic medicine; Sequence Homology, Amino Acid; Molecular Sequence Data; bcs; Protein Structure, Tertiary; 03 medical and health sciences; Bacterial Proteins; Animals; Cytokines; Muramidase; Amino Acid Sequence; Sequence Alignment

The novel bacterial cytokine family--resuscitation-promoting factors (Rpfs)--share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.