A Bioprinted Liver-on-a-Chip for Drug Screening Applications

• DOI: 10.1016/j.tibtech.2016.05.014
• Publication Date: 2016-06-12T09:44:18Z
• Authors: Stephanie Knowlton; Savas Tasoglu
• Keywords: Liver tissue; Organ-on-a-Chip; Spheroid; Microfluidic chip

The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device.