Effector translocation and rational design of disease resistance

• DOI: 10.1016/j.tim.2023.09.007
• Publication Date: 2023-09-29T20:12:10Z
• Authors: Gan Sha; Guotian Li
• Keywords: Gene Editing; Artificial Intelligence; Humans; Disease Resistance; Plant Diseases

The effector repertoire of a pathogen is dynamically evolving. However, the effector translocation mechanism, partly elucidated recently, may be conserved. By targeting the effector translocation machinery, rather than the individual evolving effector, rational design of durable and broad-spectrum disease resistance can be achieved, facilitated by genome-editing and artificial intelligence-enabling technologies.