Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

• DOI: 10.1016/j.tips.2021.04.002
• Publication Date: 2021-05-06T17:49:37Z
• Authors: Nahid Sharmin; Chinyere Chioma N...; Md Talat Nasim
• Keywords: TGF-β; 0301 basic medicine; Pulmonary Arterial Hypertension; Hypertension, Pulmonary; Pulmonary arterial hypertension; 3. Good health; ALK5 inhibitor; 03 medical and health sciences; Pulmonary vasculature; Transforming Growth Factors; BMP; Humans; Signal Transduction

Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.