Building unconventional G protein-coupled receptors, one block at a time

• DOI: 10.1016/j.tips.2021.04.005
• Publication Date: 2021-05-10T04:09:45Z
• Authors: Pradipta Ghosh; Madhubanti Mullick
• Keywords: 0301 basic medicine; Biomedical and Clinical Sciences; 1.1 Normal biological development and functioning; Pharmacology and Pharmaceutical Sciences; Biological Sciences; 540; Medical and Health Sciences; Heterotrimeric GTP-Binding Proteins; GPCRs; Toll-like receptors; Receptors, G-Protein-Coupled; G-Protein-Coupled; Frizzled; guanine-nucleotide exchange modulators; 03 medical and health sciences; Pharmacology and pharmaceutical sciences; Receptors; growth factors; integrins; Generic health relevance; Pharmacology & Pharmacy; Signal Transduction

The structure, function, and dynamics of canonical activation of heterotrimeric G proteins by the seven-transmembrane G protein-coupled receptors (GPCRs) have been illustrated in detail. However, emerging studies during the past decade have started to shed light on how the same G proteins may also be accessed and modulated by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical GPCRs?