Value of plasma neutrophil gelatinase-associated lipocalin (NGAL) in distinguishing between acute kidney injury (AKI) and chronic kidney disease (CKD)

• DOI: 10.1016/j.tjem.2017.03.002
• Publication Date: 2017-06-03T23:15:15Z
• Authors: Seref Kerem Corba...; Yunsur Cevik; Emine Akinci; Hüseyin Uzunosman...; Seda Dagar; Tuba Safak; Veysel Oncul; Murat Guvendi
• Keywords: Neutrophil gelatinase-associated lipocalin

In this study, we aimed to determine whether plasma NGAL levels could be used as a biomarker for distinguishing between AKI and CKD in emergency medicine. This prospective study was conducted at the ED of training research hospital over six-month period 2015. Three groups were defined: an group – defined new onset least 1.5-fold or ≥0.3 mg increment increase SCr values from normal baseline, stable only included presence stages 2 through 4 according National Kidney Foundation's KDIGO 2012, control group. After initial evaluation patients, venous blood samples taken routine biochemical, counter cell, measurement admission. A total 25 patients with AKI, 22 CKD, subjects enrolled. Level higher than those (median: 794 ng/ml IQR: 317–1300 & 390 219–664, p < 0.001). AUC measured 0.68 (p = 0.02, 95% CIs: 0.54–0.84) assess utility varying cut-off CKD. For NGAL, best level found 457 (sensitivity: 72.0%, specificity: 64%). has clearly demonstrated that patients. However, clinical practice, use distinguish is limited.