Short tandem repeats genotyping of gestational choriocarcinoma – our experiences

• DOI: 10.1016/j.tjog.2023.10.004
• Publication Date: 2024-01-11T03:45:39Z
• Authors: Lajos Gergely; Vanda Repiska; Robert Petrovic; Miroslav Korbel; Ludovit Danihel; Jozef Sufliarsky; Michaela Kubickova; Helena Gbelcova; Petra Priscakova
• Keywords: Chorioepithelioma; Trophoblastic neoplasm

This short communication demonstrates how tandem repeat genotyping can identify the origin of gestational choriocarcinoma. The choriocarcinoma in our three cases was determined using repeats technique, which involved quantitative fluorescent PCR and fragmentation analysis. In Case 1 despite no medical history molar pregnancy, DNA analysis indicated that originated from a homozygous complete hydatidiform mole. We conclude, patient's abortion 10 years prior to diagnosis an undiagnosed 2 3 clinically presumed confirmed. Determining is essential for clinical application, as it affects FIGO scoring system trophoblastic neoplasia, determines prognosis treatment approach.