Does probiotic Kefir reduce dyslipidemia, hematological disorders and oxidative stress induced by zearalenone toxicity in wistar rats?

• DOI: 10.1016/j.toxcx.2022.100121
• Publication Date: 2022-03-29T06:19:28Z
• Authors: Fadia Ben Taheur; Chalbia Mansour; Sondes Mechri; Sihem Safta Skhiri; Bassem Jaouadi; Ridha Mzoughi; Kamel Chaieb; Nacim Zouari
• Keywords: Kefir

Zearalenone (ZEA) is a toxic metabolite of the genus Fusarium, which causes hepatotoxicity and induces oxidative stress. Kefir an important probiotic dairy-product showing in vitro antioxidant potential. In this study, effect supplementation to mitigate ZEA toxicity rats was investigated. Animals were divided into four groups five each, received sterile milk (200 μL/day) during first week. Then, they switched μL/day), (40 mg/kg b. w./day) + for second Hematological biochemical parameters, as well liver histological analysis determined. administration prevented changes occurred count all blood cells, improved enzymes liver, such catalase, glutathione peroxidase superoxide dismutase activities that increased by 6, 4.5 1.3 folds, respectively, compared group. Interestingly, concurrent regimen removed residues serum liver. Furthermore, group showed reduction levels bilirubin, alanine aminotransferase, aspartate alkaline phosphatase hepatic malonaldehyde ∼82, 54, 66, 50 36%, The histopathological normal architecture group, while degenerative observed These results suggest consortium may have hepatoprotective against poisoning.