Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia)

• DOI: 10.1016/j.toxicon.2009.01.033
• Publication Date: 2009-02-10T13:26:51Z
• Authors: Isolete Pauli; João Carlos Minozzo; Paulo Henrique da...; Olga Meiri Chaim; Silvio Sanches Veiga
• Keywords: Antivenom

Bites by the brown spider (Loxosceles spp.) are an important health problem in South America, where three species predominate laeta, Loxosceles gaucho, intermedia). Brown bites (loxoscelism) induce a block of cutaneous necrosis and, less commonly, may cause fatal systemic poisoning. A variety controversial protocols used to treat loxoscelism, while treatment with antivenin is only venom specific treatment. Here we studied action as well response for through experimental study that simulates L. intermedia (bites this most common Brazil). Beneficial effects known applied quickly (within 4 h) after envenomation. wished examine temporal development bite patterns determine time limits beneficial use This information since patients appear several hours being bitten. New Zealand rabbits were experimentally exposed from spiders injection (2x minimum necrotic dose), followed at regular intervals antivenin. The loxoscelic antivenin--CPPI (4 mL per animal)--minimized envenomation when up 12 h venom, evaluated (erythrema, edema, ecchymosis and necrosis) (blood cell platelet counts, hematimetrics fibrinogen dosage) criteria. Also, reduced size area 48 Thus, therapy antivenin, CPPI, provide results interfering occurred therefore become tool medical bites.