Specialization of the sting venom and skin mucus of Cathorops spixii reveals functional diversification of the toxins

• DOI: 10.1016/j.toxicon.2012.02.002
• Publication Date: 2012-02-21T18:38:27Z
• Authors: Anderson Daniel R...; Katia Conceição; Pedro Ismael Silva; Michael Richardson; Carla Lima; Mônica Lopes-Ferr...
• Keywords: Sting

Cathorops spixii is the most common venomous fish on Brazilian coast. Apart from involvement with defense against pathogens, possible contribution of skin mucus components to development injuries caused by species has not been investigated. Thus, present study was conducted gain a better understanding peptide and protein sting venom catfish C. spixii. Our results show that have distinct constituents distinguished them like structural proteins, chaperones, ion transport, carbohydrate metabolism, oxidoreductase, cell cycle binding in tropomyosin 3 isoform 2 energy metabolim proteins mucus. But group 13 we identified isolated WAP65 protein. The fractions more harmful effects, such as venular stasis, hemorrhage changes arteriolar wall diameter, produced typical inflammatory process post-capillary venules. And finally showed for first time presence using LC/MS/MS also purified this venom. Wap65 shows action, working at different doses inducing an increase number leukocytes rolling adhering endothelium.