Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice

• DOI: 10.1016/j.toxrep.2015.02.010
• Publication Date: 2015-02-28T19:31:26Z
• Authors: Johanna Bodin; Anette Kocbach Bø...; Anna Wendt; Lena Eliasson; Rune Becher; Frieke Kuper; Martinus Løvik; Unni Cecilie Nygaard
• Keywords: Insulitis; NOD mice; Xenoestrogen; Endocrine disruptor

Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development in non-obese diabetic (NOD) mice. Here, we hypothesized oral exposure mixture endocrine disruptors BPA phthalates, relevant for human exposure, would accelerate compared alone. NOD mice were exposed (1 mg/l), phthalates (DEHP mg/l, DBP 0.2 BBP 10 mg/l DiBP 20 mg/l) or combination phthalate through drinking water from conception throughout life. Previous observations increased prevalence insulitis decreased number tissue resident macrophages pancreas confirmed, extended demonstrating also impaired phagocytic activity peritoneal macrophages. None these effects observed after The with seemed dampen on macrophage function as well development, but not development. Exposure alone cytokine release (TNFα, IL-6, IL-10, IFNγ, IL-4) vitro stimulated splenocytes lymph node cells, indicating systemic changes immune function. In conclusion, BPA, mixed accelerated mice, apparently part via alterations including