Organochlorine pesticide levels in Greek patients with Parkinson’s disease

• DOI: 10.1016/j.toxrep.2020.03.011
• Publication Date: 2020-04-08T04:09:59Z
• Authors: Efthimios Dardiotis; Athina-Maria Aloizou; Evagelos Sakalakis; Vasileios Siokas; Michalis Koureas; Georgia Xiromerisiou; Efthymia Petinaki; Martin Wilks; Aristidis Tsatsakis; Christos Hadjichr...; Leonidas Stefanis; Georgios M. Hadji...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; RA1190-1270; Toxicology. Poisons; Parkinson’s disease; Environmental factors; PD; organochlorines; Regular Article; 3. Good health

Parkinson's disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are class of widely-used pesticides that have been included among the list environmental factors incriminated in PD pathogenesis. However, most studies reporting this association based on questionnaires, and few reported exposure data. To examine relationship between OC blood concentrations risk. In present study, we studied 8 compounds (hexachlorobenzene, heptachlor, hepachlor epoxide, c-chlordane, a-chlordane, p,p'-DDE, DDD, DDT) 104 Greek patients 110 healthy controls. All substances were at least one sample. The frequently detected (above level quantification) p,p'-DDE (n = 214, 100 % both groups) hexachlorobenzene, HCB 189, cases 46.5 %, controls 53.5 %). Higher levels DDE comparison to by using logistic regression analysis control for confounders [Odds Ratio, OR (95 confidence interval, C.I.)]: 2.592,(1.29-5.21)], whilst lower detect [OR,95 %CI:0.176(0.09-0.35)]. Our data suggest specific OCs related risk PD. Further studies, real data, needed order confirm extend these findings.