Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease

• DOI: 10.1016/j.toxrep.2020.06.001
• Publication Date: 2020-06-05T08:56:06Z
• Authors: Doha H. Abou Baker; Bassant M.M. Ibrahim; Nabila S. Hassan; A.F Yousuf; Souad El Gengaihi
• Keywords: Flavonoids; 0301 basic medicine; Citrus aurantium seeds; 03 medical and health sciences; Acetylcholine esterase; RA1190-1270; Toxicology. Poisons; Tau protein; Regular Article; Alzheimer disease; Lemonoids; 3. Good health

Fruit by-products are considered nature's golden gift for human health and a good starting point to discover new drugs depending on the fact that they contain millions of bio-active compounds responsible therapeutic activities. In this context, main goal study is recycle Citrus aurantium (C. aurantium) seeds produce pharmaceutical molecules be used in prevention progressive neurological damage associated with Alzheimer disease (AD). Donepezil (0.75 mg/kg), hesperidin (125 250 mg/kg) limonoids (50 100 were treatment rats 2 weeks prior concomitant administration AlCl3 three successive weeks. Protection against cognitive deterioration was observed among group insignificant difference from normal control significant positive Y-Maze test. On other hand, both doses high dose only (100 produced improvement psychological state, by increase ambulation frequency comparison group, however it not as frequent significantly less than open field Regarding acetylcholine esterase (AChE) beta-amyloid (β amyloid) levels, effect low best didn't have when compared control, also showed effects β amyloid levels group. Our results encourage use C. which wasted huge amounts, prophylactic food additives.