Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation in vitro and in vivo

• DOI: 10.1016/j.toxrep.2021.02.005
• Publication Date: 2021-02-07T07:02:45Z
• Authors: Yu-Lin Dai; Yun-Fei Jiang; Yu-An Lu; Jiang-Bo Yu; Min-Cheol Kang; You-Jin Jeon
• Keywords: HaCaT; Sargassum

Particulate matter (PM) contributes to air pollution and primarily originates from unregulated industrial emissions seasonal natural dust emissions. Fucoxanthin (Fx) is a marine pigment brown macroalgae that has been shown have various beneficial effects on health. However, the of Fx PM-induced toxicities in cells animals not assessed. In this study, we investigated anti-inflammatory potential Fx-rich fraction (FxRF) Sargassum fusiformis against PM-mediated inflammatory responses. The FxRF composition was analyzed by rapid-resolution liquid chromatography mass spectrometry. other main pigments were identified. attenuated production components, including prostaglandin E2 (PGE2), cyclooxygenase-2, interleukin (IL)-1β, IL-6 PM-exposed HaCaT keratinocytes. PM exposure also reduced levels nitric oxide (NO), tumor necrosis factor-α, inducible synthase (iNOS), PGE2 RAW264.7 macrophages. Additionally, culture medium induced upregulation NO, iNOS, PGE2, pro-inflammatory cytokines significantly decreased expression factors involved responses, such as reactive oxygen species, cell death, zebrafish embryos. These results demonstrated protective inflammation both vitro model.