Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure

• DOI: 10.1016/j.toxrep.2021.03.006
• Publication Date: 2021-03-10T02:21:30Z
• Authors: Terry C. Hrubec; Ryan P. Seguin; Libin Xu; Gino A. Cortopassi; Sandipan Datta; Alexandra L. Hanlon; Alicia J. Lozano; Valerie A. McDonald; Claire A. Healy; Tyler C. Anderson; Najaha A. Musse; Richard T. Williams
• Keywords: Disinfectant; Homeostasis

Humans are frequently exposed to Quaternary Ammonium Compounds (QACs). QACs ubiquitously used in medical settings, restaurants, and homes as cleaners disinfectants. Despite their prevalence, nothing is known about the health effects associated with chronic low-level exposure. Chronic QAC toxicity, only recently identified mice, resulted developmental, reproductive, immune dysfunction. Cell based studies indicate increased inflammation, decreased mitochondrial function, disruption of cholesterol synthesis. If these findings translate human multiple physiological processes could be affected. This study tested whether concentrations detected blood 43 volunteers, influenced markers were 80 % participants. Blood increase inflammatory cytokines, homeostasis a dose dependent manner. first measure blood, also demonstrate statistically significant relationships between meaningful related biomarkers. Additionally, results timely light disinfectant exposure occurring due SARS-CoV-2 pandemic.