Experience in South Africa of combining bioanalysis and instrumental analysis of PCDD/Fs

• DOI: 10.1016/j.trac.2013.02.003
• Publication Date: 2013-03-05T10:04:59Z
• Authors: Jayne de Vos; Laura Quinn; Laura Quinn; Claudine Roos; Rialet Pieters; Henk Bouwman; Peter Gorst-Allman; Egmont Rohwer; John P. Giesy
• Keywords: Bioanalysis

We outline the experiences and the challenges of optimizing two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOF-MS) in conjunction with the H4IIE-luc bio-assay for analyzing polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the South African context. Investigating such alternative analytical methods can assist countries with developing economies to meet their obligations under the Stockholm Convention.