Biochemical analysis on microfluidic chips

• DOI: 10.1016/j.trac.2016.03.013
• Publication Date: 2016-03-14T18:32:44Z
• Authors: Jing Wu; Ziyi He; Qiushui Chen; Jin-Ming Lin
• Keywords: Microscale chemistry; Biomimetics; Lab-on-a-Chip; Microfluidic chip

Abstract Biochemical analysis is crucial in understanding mechanism of life activities and giving biological insights into life process. With inherent merits in flexible design, microscale of operation, good incorporation with other techniques for manipulation and detection, microfluidic chip has introduced new paradigms in biochemical analysis field. Considering the explosive development of microfluidics over the past decades, in this review, we summarized recent advances in biochemical analysis on microfluidic platforms. Highlight was put on the integrated technologies such as optical, electrical, acoustic and magnetic techniques. Focus also was given on relative applications in biomimetics, drug screening, biomolecular detection, single cell and stem cell analysis.