Calibration-free potentiometric sensing with solid-contact ion-selective electrodes

• DOI: 10.1016/j.trac.2021.116277
• Publication Date: 2021-03-23T19:24:20Z
• Authors: Celeste R. Rousseau; Philippe Bühlmann
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract In recent years, an important aspect of research into the improvement of ion-selective electrodes (ISEs) has been the development of solid-contact ISEs for calibration-free measurements, with the goal of sensors that can be implemented with ease for long-term, in situ analysis with very limited or no maintenance. This review discusses the definition of the term “calibration-free” in this context, and it gives suggestions as to what types of information should be reported if a claim of calibration-free usage is made. Relevant literature in this field is reviewed, with a focus on different mechanisms of ion-to-electron signal transduction. Different types of redox-active, capacitive, and mixed-mechanism transduction modes are discussed in view of the reproducibility and stability of the potential responses they provide.