Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women

• DOI: 10.1016/j.tranon.2021.101086
• Publication Date: 2021-04-08T04:14:04Z
• Authors: Mansoor Saleh; Darshan Shimoga C...; Sayed Shahin; Sumit Agarwal; Hyung-Gyoon Kim; Michael Behring; Asim Jamal Shaikh; Zahir Moloo; Isam-Eldin A Eltoum; Clayton Yates; Sooryanarayana Va...; Upender Manne
• Keywords: Triple-negative breast cancer

: Triple-negative breast cancer (TNBC) patients of various ethnic groups often have discrete clinical presentations and outcomes. Women African descent a disproportionately higher chance developing TNBCs. The aim the current study was to establish transcriptome TNBCs from Kenyan (KE) women Bantu origin compare it those African-Americans (AA) Caucasians (CA) for identifying KE TNBC-specific molecular determinants progression potential biomarkers Pathology-confirmed TNBC tissues (n = 15) age stage range matched AA 19) CA 23) Alabama were included in this study. RNA isolated paraffin-embedded tissues, expression analyzed by sequencing. At presentation, young tumors stages. Differential analysis identified 160 up-regulated 178 down-regulated genes compared Validation analyses TCGA data 45 that are involved apoptosis (ACTC1, ERCC6 CD14), cell proliferation (UHRF2, KDM4C, UHMK1, KCNH5, KRT18, CSF1R S100A13), Wnt signaling (BCL9L) pathways. In study, we specific origin. Further with larger sample size could confirm our findings. If biologically confirmed, these biological implications serve as targets development personalized therapeutics patients.